Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome
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چکیده
منابع مشابه
Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome.
The molecular physiology underlying human milk production is largely unknown because of limitations in obtaining tissue samples. Determining gene expression in normal lactating women would be a potential step toward understanding why some women struggle with or fail at breastfeeding their infants. Recently, we demonstrated the utility of RNA obtained from breast milk fat globule (MFG) to detect...
متن کاملCALL FOR PAPERS Comparative Genomics Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome
Maningat PD, Sen P, Rijnkels M, Sunehag AL, Hadsell DL, Bray M, Haymond MW. Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome. Physiol Genomics 37: 12–22, 2009. First published November 18, 2008; doi:10.1152/physiolgenomics.90341.2008.—The molecular physiology underlying human milk production is largely unknown because of limitations in obtaini...
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While milk proteins have been studied for decades, strikingly little effort has been applied to determining how the post-translational modifications (PTMs) of these proteins may change during the course of lactation. PTMs, particularly glycosylation, can greatly influence protein structure, function, and stability and can particularly influence the gut where their degradation products are poten...
متن کاملRNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation
Aware of the important benefits of human milk, most U.S. women initiate breastfeeding but difficulties with milk supply lead some to quit earlier than intended. Yet, the contribution of maternal physiology to lactation difficulties remains poorly understood. Human milk fat globules, by enveloping cell contents during their secretion into milk, are a rich source of mammary cell RNA. Here, we pai...
متن کاملBovine Mammary Gene Expression Profiling during the Onset of Lactation
BACKGROUND Lactogenesis includes two stages. Stage I begins a few weeks before parturition. Stage II is initiated around the time of parturition and extends for several days afterwards. METHODOLOGY/PRINCIPAL FINDINGS To better understand the molecular events underlying these changes, genome-wide gene expression profiling was conducted using digital gene expression (DGE) on bovine mammary tiss...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2009
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.90341.2008